The publications in the e-Scripta section are selected, reviewed and revised papers delivered at El’Manuscript 2021 (Freiburg/online) in April, 2021 (www. elmanuscript2021.uni-freiburg.de). El’Manuscript is a series of biennial international conferences entitled “Textual Heritage and Information Technologies” that brings together linguists, specialists in historical source criticism, IT specialists, and others involved in publishing and studying our textual heritage. It is the official conference of the Special Commission on the Computer-Supported Processing of Mediæval Slavonic Manuscripts and Early Printed Books to the International Committee of Slavists. In the 2021 iteration, it coincided with the meeting of the Humboldt research group linkage program DigiPalSlav (Slavic Department at Freiburg University and Institute for the Russian Language, Russian Academy of Sciences, Moscow) devoted to developing and applying digital tools for pre-modern Orthodox Slavic such as neural taggers and Handwritten Text Recognition models. These issues are also reflected in the thematic focus of the 2021 iteration of El’Manuscript and, consequently, in the topics of the papers submitted and accepted for publication. We would like to thank our external reviewers for their thorough work and for meeting our tight deadlines. Furthermore, we thank Elena Renje for her valuable support. Many thanks are due to the Humboldt Foundation for financing the publication of this volume. Finally, we are grateful to the editor of Scripta & e-Scripta, Anissava Miltenova, for her tireless work and support.